Table 3.
Cell type expressing MMPs and TIMPs in primary tumors from patients without tumoral recurrence, from patients with local recurrences, from patients with distant metastasis, and in local recurrences
| Factor | Primary tumors of patients without recurrence | Primary tumors of patients with local recurrence | Primary tumors of patients with distant metastasis | Univariate p value* | Multivariate p value* | Local recurrences |
|---|---|---|---|---|---|---|
| N (%) | N (%) | N (%) | N (%) | |||
| MMP-1 | ||||||
| Tumoral cell | 41 (85.4) | 16 (66.7) | 47 (94) | 0.008 | 0.02 | 11 (45.8) |
| Fibroblast | 38 (79.2) | 4 (16.7) | 45 (90) | 0.0001 | 0.001 | 3 (12.5) |
| MIC | 31 (64.6) | 3 (12.5) | 36 (72) | 0.0001 | 0.001 | 4 (16.7) |
| MMP-2 | ||||||
| Tumoral cell | 12 (25) | 5 (20) | 21 (42) | 0.08 | n.s. | 7 (28) |
| Fibroblast | 8 (16.7) | 4 (16) | 15 (30) | n.s. | n.s. | 6 (24) |
| MIC | 0 | 0 | 1 (2) | n.s. | n.s. | 0 |
| MMP-7 | ||||||
| Tumoral cell | 39 (83) | 6 (24) | 46 (92) | 0.0001 | 0.0001 | 3 (12) |
| Fibroblast | 29 (61.7) | 1 (4) | 41 (82) | 0.0001 | 0.001 | 1 (4) |
| MIC | 20 (42.6) | 1 (4) | 32 (64) | 0.0001 | 0.0001 | 0 |
| MMP-9 | ||||||
| Tumoral cell | 29 (58) | 9 (36) | 44 (89.8) | 0.0001 | 0.012 | 16 (64) |
| Fibroblast | 0 | 1 (4) | 27 (34.7) | 0.0001 | 0.01 | 1 (4) |
| MIC | 0 | 5 (20) | 8 (16.3) | 0.007 | 0.0001 | 4 (16) |
| MMP-11 | ||||||
| Tumoral cell | 39 (79.6) | 18 (75) | 46 (93.9) | 0.05 | 0.005 | 19 (79.2) |
| Fibroblast | 19 (38.8) | 15 (62.5) | 43 (87.8) | 0.0001 | 0.05 | 19 (79.2) |
| MIC | 0 | 13 (54.2) | 27 (55.1) | 0.0001 | 0.0001 | 15 (62.5) |
| MMP-13 | ||||||
| Tumoral cell | 37 (74) | 15 (68.2) | 40 (80) | n.s. | n.s. | 14 (63.6) |
| Fibroblast | 14 (28) | 3 (13.6) | 36 (72) | 0.0001 | 0.0001 | 7 (31.8) |
| MIC | 8 (16) | 0 | 28 (56) | 0.0001 | 0.01 | 2 (9.1) |
| MMP-14 | ||||||
| Tumoral cell | 45 (90) | 14 (60.9) | 45 (90) | 0.002 | n.s. | 13 (56.6) |
| Fibroblast | 40 (80) | 4 (17.4) | 39 (78) | 0.0001 | 0.001 | 2 (8.7) |
| MIC | 11 (22) | 3 (13) | 35 (70) | 0.0001 | 0.01 | 7 (30.4) |
| TIMP-1 | ||||||
| Tumoral cell | 45 (90) | 24 (100) | 48 (96) | n.s. | n.s. | 24 (100) |
| Fibroblast | 24 (48) | 19 (79.2) | 26 (52) | 0.03 | n.s. | 21 (87.5) |
| MIC | 3 (6) | 20 (83.3) | 24 (48) | 0.0001 | 0.0001 | 22 (91.7) |
| TIMP-2 | ||||||
| Tumoral cell | 39 (78) | 23 (95.8) | 47 (94) | 0.02 | n.s. | 24 (100) |
| Fibroblast | 6 (12) | 21 (87.5) | 33 (66) | 0.0001 | 0.0001 | 20 (83.3) |
| MIC | 5 (10) | 20 (83.3) | 27 (54) | 0.0001 | 0.0001 | 20 (83.3) |
| TIMP-3 | ||||||
| Tumoral cell | 44 (88) | 18 (72) | 41 (82) | n.s. | n.s. | 19 (76) |
| Fibroblast | 19 (38) | 16 (64) | 36 (72) | 0.002 | 0.01 | 10 (40) |
| MIC | 20 (40) | 2 (8) | 28 (56) | 0.0001 | 0.008 | 3 (20) |
n.s. not significant
* p value for comparing the three groups of primary tumors