Figure 2:
Silencing of PLK1 promotes autophagy in lung cancer cells and inhibits cancer progression. (a and b) Induction of ROS increase in lung cancer cells through silencing of PLK1. (c and d) Induction of autophagy in lung cancer cells through silencing of PLK1. (e) Accumulation of autophagosomes in lung cancer cells through PLK1 silencing. n = 3 (✶P < 0.05, ✶✶P < 0.01, ✶✶✶ P < 0.001). PTEN: Phosphatase and tensin homolog deleted on chromosome ten, ATG5: Autophagy protein 5, PLK1: Polo-like kinase 1, ROS: Reactive oxygen species, Ov-NC: negative control to overexpression plasmid, Ov-PTEN: PTEN overexpression plasmid.
