TABLE 3.
Functional Tumor Volume Measurements in Patients With and Without Pathologic Complete Response (pCR)
| Measure | Optimal threshold | AUC [95% CI] | P | Mean ± SD volume, cm3 | ||
|---|---|---|---|---|---|---|
| pCR | Non-pCR | |||||
| BL Scan | ||||||
| FTV1-min | PE > 0 SER > 0 |
0.59 [0.45,0.74] | 0.23 | 15 ± 31 | 19 ± 24 | |
| FTV2.5-min | PE > 0 SER > 0 |
0.60 [0.46,0.75] | 0.18 | 15 ± 35 | 18 ± 22 | |
| FTVOpt | Early Phase = 30 s PE > 0 SER > 1.3 |
0.69 [0.55,0.82] | <0.05 | 0.12 ± 0.34 | 0.32 ± 0.62 | |
| C4 scan | ||||||
| FTV1-min | PE > 40 SER > 0.5 |
0.85 [0.74,0.95] | <0.05 | 0.12 ± 0.25 | 3.2 ± 6.2 | |
| FTV2.5-min | PE > 95 SER > 0.8 |
0.83 [0.72,0.94] | <0.05 | 0.17 ± 0.47 | 2.7 ± 5.4 | |
| FTVOpt | Early Phase = 60 s PE > 40 SER > 0.35 |
0.85 [0.75,0.96] | <0.05 | 0.13 ± 0.26 | 3.5 ± 7.2 | |
| %C4/BL | % change | % change | ||||
| FTV1-min | PE > 130 SER > 1.1 |
0.82 [0.71,0.93] | <0.05 | −99% ± 0.20% | −89% ± 7.0% | |
| FTV2.5-min | PE > 120 SER > 0.85 |
0.79 [0.66,0.91] | <0.05 | −93% ± 24% | −62% ± 63% | |
| FTVOpt | Early Phase = 60 s PE > 115 SER > 0.75 |
0.85 [0.74,0.95] | <0.05 | −100% ± 1.7% | −47% ± 110% | |
AUC, area under the receiver operator characteristic curve; BL, baseline; CI, confidence interval; NA, not applicable; ETV, enhanced tumor volume; FTV, functional tumor volume; PE, percentage enhancement; SER, signal enhancement ratio; Opt, optimal; C4, cycle 4.