Table 2.
TB preventive therapies and their side effects.
| Drug(s) | Dosage | Time | Major side effects | Pyridoxine supplementation |
|---|---|---|---|---|
| INH | 5 mg/kg/die (max 300 mg/die) |
6 months | Liver, peripheral neuropathy | Recommended |
| INH | 5 mg/kg/die (max 300 mg/die) |
9 months | Liver, peripheral neuropathy | Recommended |
| Rifampicin | 10 mg/kg/die (max 600 mg/die) |
4 months | Liver | |
| INH+ Rifampicin | 3 months | Liver, peripheral neuropathy | Recommended | |
| Rifapentine+ INH | Isoniazid 900 mg/weekly Rifapentine 900 mg/weekly |
3 months | Liver, peripheral neuropathy, SDR* | Recommended |
| Rifapentine+ INH | Isoniazid 300 mg/day Rifapentine 600 mg/day | 1 month | Liver, peripheral neuropathy | Recommended |
| Levofloxacin | <45 kg 750 mg/day; > 45 kg, 1g/day |
Tenosynovitis, QT elongation, gastrointestinal symptoms |
SDR, systemic drug reaction, defined as either (1) hypotension, urticaria, angioedema, acute bronchospasm, or conjunctivitis; or (2) >4 flu-like symptoms, Age Impact on 3HP with >1 being grade 2 or higher.
The name of the drugs is highlighted in bold.