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The inhibitory effects of FLINs 1-6 on FLT3-ITD and MV4-11 cells.
| Compounds | FLT3-ITD (IC50, nM) | MV4-11 (IC50, nM) |
|---|---|---|
| FLIN-1 | 10.24 ± 0.81 | 12.19 ± 0.94 |
| FLIN-2 | 4.98 ± 0.35 | 5.54 ± 0.41 |
| FLIN-3 | 2.85 ± 0.22 | 3.03 ± 0.27 |
| FLIN-4 | 1.07 ± 0.04 | 1.31 ± 0.06 |
| FLIN-5 | 14.52 ± 0.98 | 17.66 ± 1.03 |
| FLIN-6 | 6.39 ± 0.47 | 8.28 ± 0.54 |
| Midostaurin | 29.64 ± 1.45 | 40.03 ± 1.62 |
