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. 1987 Feb;383:395–404. doi: 10.1113/jphysiol.1987.sp016415

Spinal cord influences on the colonic myoelectrical activity of fed and fasted rats.

C Du 1, J P Ferré 1, Y Ruckebusch 1
PMCID: PMC1183076  PMID: 3656127

Abstract

1. The myoelectrical activity of the large intestine of fed and fasted rats was recorded with chronically implanted nichrome wire electrodes after destruction of the spinal cord, after spinal cord transection, and after spinal anaesthesia. 2. After spinal cord ablation, the cyclical organization of the colonic electrical spiking activity, as well as the gastrocolic reflex and accompanying postprandial enhancement of the cyclical pattern of activity, persisted on the proximal and distal colon. On the transverse colon, however, the spiking activity was considerably increased. This latter effect obliterated the gastrocolic response due to feeding but not the subsequent postprandial enhancement of the cyclical pattern of activity. 3. After spinal cord transection, the level of spiking activity also increased on both the transverse and distal colon, but no major changes in cyclical activity or in postprandial responses were recorded. 4. Spinal anaesthesia produced by intrathecal lidocaine increased the motility of the transverse colon to a level which masked the gastrocolic reflex. 5. These results suggest a prevertebral ganglia and/or a local control mechanism for the cyclical organization of the spiking activity of the colon. The central control mechanisms involve mostly spinal inhibitory influences on the transverse colon and supraspinal inhibitory influences on the distal colon.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aaronson M. J., Freed M. M., Burakoff R. Colonic myoelectric activity in persons with spinal cord injury. Dig Dis Sci. 1985 Apr;30(4):295–300. doi: 10.1007/BF01403836. [DOI] [PubMed] [Google Scholar]
  2. CONNELL A. M., FRANKEL H., GUTTMANN L. THE MOTILITY OF THE PELVIC COLON FOLLOWING COMPLETE LESIONS OF THE SPINAL CORD. Paraplegia. 1963 Sep;1:98–115. doi: 10.1038/sc.1963.9. [DOI] [PubMed] [Google Scholar]
  3. Commissiong J. W. The synthesis and metabolism of catecholamines in the spinal cord of the rat after acute and chronic transections. Brain Res. 1985 Nov 11;347(1):104–111. doi: 10.1016/0006-8993(85)90893-5. [DOI] [PubMed] [Google Scholar]
  4. De Groat W. C., Krier J. The central control of the lumbar sympathetic pathway to the large intestine of the cat. J Physiol. 1979 Apr;289:449–468. doi: 10.1113/jphysiol.1979.sp012746. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Faden A. I., Jacobs T. P., Helke C. J. Changes in substance P and somatostatin in the spinal cord after traumatic spinal injury in the rat. Neuropeptides. 1985 Jun;6(3):215–225. doi: 10.1016/0143-4179(85)90092-7. [DOI] [PubMed] [Google Scholar]
  6. Fealey R. D., Szurszewski J. H., Merritt J. L., DiMagno E. P. Effect of traumatic spinal cord transection on human upper gastrointestinal motility and gastric emptying. Gastroenterology. 1984 Jul;87(1):69–75. [PubMed] [Google Scholar]
  7. Ferré J. P., Ruckebusch Y. Myoelectrical activity and propulsion in the large intestine of fed and fasted rats. J Physiol. 1985 May;362:93–106. doi: 10.1113/jphysiol.1985.sp015665. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Gardette B., Gonella J. Etude électromyographique in vivo de la commande nerveuse orthosympathique du côlon chez le chat. J Physiol (Paris) 1974;68(6):671–692. [PubMed] [Google Scholar]
  9. Garry R. C. The nervous control of the caudal region of the large bowel in the cat. J Physiol. 1933 Mar 15;77(4):422–431. doi: 10.1113/jphysiol.1933.sp002977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Gregory R. A. Some factors influencing the passage of fluid through intestinal loops in dogs. J Physiol. 1950 Apr 15;111(1-2):119–137. doi: 10.1113/jphysiol.1950.sp004468. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Hadjiconstantinou M., Panula P., Lackovic Z., Neff N. H. Spinal cord serotonin: a biochemical and immunohistochemical study following transection. Brain Res. 1984 Nov 26;322(2):245–254. doi: 10.1016/0006-8993(84)90114-8. [DOI] [PubMed] [Google Scholar]
  12. Hertz A. F., Newton A. The normal movements of the colon in man. J Physiol. 1913 Oct 17;47(1-2):57–65. doi: 10.1113/jphysiol.1913.sp001613. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Hultén L. Extrinsic nervous control of colonic motility and blood flow. An experimental study in the cat. Acta Physiol Scand Suppl. 1969;335:1–116. [PubMed] [Google Scholar]
  14. Kreulen D. L., Szurszewski J. H. Reflex pathways in the abdominal prevertebral ganglia: evidence for a colo-colonic inhibitory reflex. J Physiol. 1979 Oct;295:21–32. doi: 10.1113/jphysiol.1979.sp012952. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Latour A., Ferré J. P. Computer-aided analysis of gastrointestinal myoelectric activity. J Biomed Eng. 1985 Apr;7(2):127–131. doi: 10.1016/0141-5425(85)90041-x. [DOI] [PubMed] [Google Scholar]
  16. Lisander B., Stenqvist O. Epidural fentanyl counteracts sympathetic gastric inhibition. Acta Anaesthesiol Scand. 1985 Aug;29(6):560–565. doi: 10.1111/j.1399-6576.1985.tb02254.x. [DOI] [PubMed] [Google Scholar]
  17. Ruckebusch Y., Ferré J. P., Du C. In vivo modulation of intestinal motility and sites of opioid effects in the rat. Regul Pept. 1984 Sep;9(1-2):109–117. doi: 10.1016/0167-0115(84)90013-2. [DOI] [PubMed] [Google Scholar]
  18. Sharkey K. A., Williams R. G., Dockray G. J. Sensory substance P innervation of the stomach and pancreas. Demonstration of capsaicin-sensitive sensory neurons in the rat by combined immunohistochemistry and retrograde tracing. Gastroenterology. 1984 Oct;87(4):914–921. [PubMed] [Google Scholar]
  19. Tansy M. F., Kendall F. M., Murphy J. J. The reflex nature of the gastrocolic propulsive response in the dog. Surg Gynecol Obstet. 1972 Sep;135(3):404–410. [PubMed] [Google Scholar]
  20. Yaksh T. L., Rudy T. A. Chronic catheterization of the spinal subarachnoid space. Physiol Behav. 1976 Dec;17(6):1031–1036. doi: 10.1016/0031-9384(76)90029-9. [DOI] [PubMed] [Google Scholar]

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