Table 3.

The effects of microRNAs on cancerogenesis in gliomas.

	Tumor suppressive miRNA	Cancerogenic miRNAs
Downregulated in gliomas	miR-7, miR-34a, miR-124, miR-128, miR-137, miR-181 (Banelli et al., 2017; Tluli et al., 2023; Silber et al., 2008) miR-7, miR-34a and miR-12 (Chen M. et al., 2021) miR-128 (Godlewski et al., 2008)	RAS inhibitor Let-7 (Lee et al., 2011)
Upregulated in gliomas	anti-tumor effect miR-128-3p or miR-145-5p (Goenka et al., 2022) inhibition of tumor-suppressing gene miR-19a, miR-19b, miR-20a, and miR-92a (Buruiană et al., 2020) inhibition of proapoptotic p53 MiR-221/222 (Chen et al., 2012)	miR-10b and miR-21 in high-grade gliomas have been linked to angiogenesis, metastasis, and chemoresistance (Chen M. et al., 2021) Upregulated in proneural (PN) but inactive in mesenchymal (MES) GBM miR-125b and miR-20b (Huang et al., 2016) miR-10b (El Fatimy et al., 2017) miR-21 3p, and miR-21-5p (Shang et al., 2015)