Table 2.
Absolute Changes in Skeletal Muscle and Adipose Tissue Compartments During Neoadjuvant Chemoradiation and Their Association with Resection
| Pretreatment | Posttreatment | Difference | |||
|---|---|---|---|---|---|
|
| |||||
| Tissue Type | Mean (SE) | Mean (SE) | Mean (SE) | P-value | |
| Skeletal Muscle | |||||
|
| |||||
| All Patients | n=82 | 47.5 (1.0) | 46.3 (1.0) | −1.2 (0.4) | 0.01 |
| Resected | n=53 | 48.2 (1.1) | 46.9 (1.1) | −1.3 (0.5) | 0.01 |
| Non-Resected | n=29 | 46.2 (2.0) | 45.1 (2.1) | −1.1 (0.9) | 0.24 |
| P-value for Resected vs. Non-Resected | 0.40 | 0.45 | 0.87 | ||
|
| |||||
| Visceral Adipose | |||||
|
| |||||
| All Patients | n=82 | 45.1 (3.1) | 41.2 (2.8) | −4.0 (1.6) | 0.01 |
| Resected | n=53 | 44.5 (4.1) | 42.6 (3.8) | −2.0 (2.0) | 0.33 |
| Non-Resected | n=29 | 46.3 (4.6) | 38.6 (4.3) | −7.6 (2.3) | 0.003 |
| P-value for Resected vs. Non-Resected | 0.78 | 0.49 | 0.07 | ||
|
| |||||
| Subcutaneous Adipose | |||||
|
| |||||
| All Patients | n=47 | 53.0 (4.0) | 48.7 (3.5) | −4.2 (1.7) | 0.02 |
| Resected | n=31 | 53.5 (5.1) | 51.4 (3.9) | −2.1 (1.9) | 0.29 |
| Non-Resected | n=16 | 51.9 (6.4) | 43.6 (7.1) | −8.4 (3.3) | 0.02 |
| P-value for Resected vs. Non-Resected | 0.85 | 0.34 | 0.11 | ||
Note, median (min, max) treatment time was 4.2 months (2.2, 11.5 months), n=87. Units are cm2/m2.