Table 4. Biological activities of compounds 1–7 and 9 from cultures of Hypocrella luteola TBRC-BCC 76666.
| Compounds | Antimalarial P. falciparum, K1 (IC50, μM) | Cytotoxicity (IC50, μM) | Anti-phytopathogenic fungal (MIC, μM) | |||
|---|---|---|---|---|---|---|
| NCI-H187 | MCF-7 | Vero | C. acutatum | A. brassicicola | ||
| 1 | >34.7 | 19.0 | >173.5 | 58.91 | >173.5 | >173.5 |
| 2 | >33.1 | >165.4 | >165.4 | >165.4 | >165.4 | >165.4 |
| 3 | >34.9 | >174.6 | >174.6 | >174.6 | >174.6 | >174.6 |
| 4 | >32.0 | >160.1 | 42.5 | >160.1 | >160.1 | >160.1 |
| 5 | >16.5 | 9.9 | >82.4 | 21.6 | >82.4 | >82.4 |
| 6 | >21.5 | >107.7 | >107.7 | >107.7 | >107.7 | >107.7 |
| 7 | >45.0 | >225.1 | >225.1 | >225.1 | >225.1 | >225.1 |
| Ascherxanthone B (9) | 13.5 | 0.9 | 30.5 | 4.7 | 5.1 | 5.1 |
| Dihydroartemisinina | 0.002 | — | — | — | — | — |
| Chloroquine diphosphatea | 0.4 | — | — | — | — | — |
| Doxorubicinb | 0.2 | 11.9 | — | — | — | |
| Ellipticineb | 10.7 | — | 3.9 | — | — | |
| Tamoxifenb | — | 18.2 | — | — | — | |
| Amphotericin Bc | — | — | — | 3.4 | 1.7 | |
a
Positive control for antimalarial assay.
b
Positive control for cytotoxicity assay.
c
Positive control for antifungal assay.