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. 2025;28(4):401–408. doi: 10.22038/ijbms.2025.82513.17836

Figure 5.

Vortioxetine inhibits activation of the PI3K-Akt signaling pathway

Figure 5

DEGs regulated by vortioxetine were analyzed for functional enrichment using the STRING database (A). A172 and U251 cells were treated with increasing concentrations of vortioxetine. Western blot analysis was performed to assess the expression levels of PI3K/Akt pathway proteins (B).

DEGs: Differentially expressed genes