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. 2025;28(4):434–443. doi: 10.22038/ijbms.2025.79808.17287

Figure 3.

PPI network analysis. The PPI network resulting from the analysis consisted of 57 nodes interconnected by 542 edges, representing potential protein-protein interactions among the identified genes

Figure 3

Genes are depicted in rectangle format, while interactions are represented by lines connecting the nodes. Within this complex network, specific genes exhibited higher connectivity and centrality, indicating their significance in the network. The top hub genes, ranked by degree method, are highlighted in red, orange, and yellow, emphasizing their central roles in the network. These top hub genes include FOXM1 (Score: 38, Log2FC: 1.359329, Adj.P.Val: 5.31E-12), KIF23 (Score: 37, Log2FC: 1.126213, Adj.P.Val: 1.07E-10), CDC20 (Score: 37, Log2FC: 1.638208, Adj.P.Val: 2.43E-15), TYMS (Score: 35, Log2FC: 1.016491, Adj.P.Val: 2.11E-18), BUB1B (Score: 35, Log2FC: 1.120616, Adj.P.Val: 6.62E-10), BIRC5 (Score: 34, Log2FC: 1.137402, Adj.P.Val: 5.74E-11), BUB1 (Score: 33, Log2FC: 1.573514, Adj.P.Val: 2.09E-13), EZH2 (Score: 33, Log2FC: 1.233123, Adj.P.Val: 5.90E-10), ANLN (Score: 33, Log2FC: 1.182217, Adj.P.Val: 3.36E-07), and PRC1 (Score: 33, Log2FC: 1.066060, Adj.P.Val: 1.50E-08).