Table 1.

Overview of the PICO (Participants intervention comparator outcomes) eligibility criteria

Participants	Cell lines subjected to phytochemicals There will be no restriction on the type of cell line and doses of phytochemicals
Intervention	Phytochemicals that have anti-adipogenesis ability
Comparator	Comparison will be between control and experiment intervention. Studies without a control group will be excluded
Outcomes	Our primary outcome is the inhibition of adipogenesis and lowering of lipid accumulation. Studies without inhibitory effects on adipogenesis will be excluded. Our secondary outcome is significant depletion of factors and/or enzymes involved in adipogenesis
Study design	Studies will be limited to experimental prospective controlled studies. Non-comparative studies, systematic reviews and meta-analyses, in vivo studies, and opinion and editorials will be excluded