Table 4.

Multivariate COX analysis of OS of HSPG2 and KIRC

		Univariate analysis		Multivariate analysis
Characteristics	Total(N)	HR(95% CI)	P value	HR(95% CI)	P value
Pathologic T stage	541
T1	279	Reference		Reference
T2	71	1.488 (0.893—2.478)	0.127	0.102 (0.008—1.338)	0.082
T3	180	3.321 (2.356—4.681)	< 0.001	0.468 (0.051—4.280)	0.501
T4	11	10.631 (5.374—21.03)	< 0.001	0.758 (0.057—10.123)	0.834
Pathologic N stage	258
N0	242	Reference		Reference
N1	16	3.422 (1.817—6.446)	< 0.001	0.368 (0.058—2.353)	0.291
Pathologic M stage	508
M0	429	Reference		Reference
M1	79	4.401 (3.226—6.002)	< 0.001	1.729 (0.144—20.81)	0.666
Serum calcium	367
Low	204	Reference		Reference
Normal	153	1.225 (0.865—1.735)	0.254	0.770 (0.437—1.357)	0.366
Elevated	10	4.846 (2.404—9.769)	< 0.001	0.621 (0.163—2.367)	0.485
Pathologic stage	538
Stage I	273	Reference		Reference
Stage II	59	1.183 (0.638—2.193)	0.594	7.364 (0.463—117.1)	0.157
Stage III	123	2.649 (1.767—3.971)	< 0.001	3.263 (0.330—32.24)	0.311
Stage IV	83	6.622 (4.535—9.670)	< 0.001	10.850 (0.378—311)	0.164
Gender	541
Female	187	Reference
Male	354	0.924 (0.679—1.257)	0.613
Age	541
< = 60	269	Reference		Reference
> 60	272	1.791 (1.319—2.432)	< 0.001	1.735 (1.016—2.965)	0.044
Histologic grade	533
G1	14	Reference		Reference
G2	236	7,606,603.7579 (0.000—Inf)	0.993	11,012,291.1484 (0.000—Inf)	0.995
G3	207	14,061,844.0831 (0.000—Inf)	0.993	10,610,528.7864 (0.000—Inf)	0.995
G4	76	38,352,819.2469 (0.000—Inf)	0.993	16,380,378.5492 (0.000—Inf)	0.995
Hemoglobin	461
Low	264	Reference		Reference
Normal	192	0.430 (0.302—0.613)	< 0.001	0.693 (0.378—1.272)	0.236
Elevated	5	2.663 (0.844—8.400)	0.095	2.234 (0.260—19.21)	0.464
Laterality	540
Left	253	Reference		Reference
Right	287	0.707 (0.525—0.952)	0.022	1.287 (0.778—2.130)	0.326
HSPG2	541
Low	270	Reference		Reference
High	271	0.447 (0.325—0.614)	< 0.001	0.545 (0.311—0.954)	0.034