Table 3.
Univariate and multivariate Cox regression analysis for PFS and OS in early stage epithelial ovarian patients
| PFS | OS | |||||||
|---|---|---|---|---|---|---|---|---|
| Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | |||||
| HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | |
| Age | ||||||||
| ≤ 53 | Ref | Ref | Ref | Ref | ||||
| > 53 | 1.31 (0.72–2.39) | 0.372 | 0.95 (0.48–1.90) | 0.895 | 1.61 (0.80–3.22) | 0.180 | 1.47 (0.67–3.22) | 0.335 |
| PNI | ||||||||
| Low | Ref | Ref | Ref | Ref | ||||
| High | 0.31 (0.16–0.59) | < 0.001 | 0.39 (0.20–0.76) | 0.006 | 0.36 (0.17–0.76) | 0.007 | 0.44 (0.20–0.97) | 0.042 |
| SII | ||||||||
| Low | Ref | Ref | Ref | Ref | ||||
| High | 2.72 (1.42–5.22) | 0.003 | 2.43 (1.23–4.81) | 0.011 | 2.43 (1.21–4.89) | 0.013 | 2.05 (0.96–4.39) | 0.064 |
| Histology | ||||||||
| HGSC | Ref | Ref | Ref | Ref | ||||
| Others | 0.71 (0.38–1.36) | 0.304 | 0.71 (0.35–1.42) | 0.335 | 1.08 (0.49–2.42) | 0.843 | 1.27 (0.52–3.08) | 0.599 |
| FIGO stage | ||||||||
| I | Ref | Ref | Ref | Ref | ||||
| IIA | 1.42 (0.66–3.07) | 0.371 | 1.26 (0.56–2.84) | 0.570 | 1.57 (0.68–3.64) | 0.295 | 1.34 (0.55–3.26) | 0.520 |
| Comorbidities | ||||||||
| No | Ref | Ref | Ref | Ref | ||||
| Yes | 1.77 (0.89–3.52) | 0.101 | 1.63 (0.75–3.56) | 0.217 | 2.39 (1.13–5.07) | 0.022 | 2.13 (0.94–4.83) | 0.071 |
| Family history of cancer | ||||||||
| No | Ref | Ref | Ref | Ref | ||||
| Yes | 0.84 (0.33–2.13) | 0.713 | 0.58 (0.22–1.53) | 0.268 | 0.68 (0.21–2.24) | 0.525 | 0.58 (0.17–1.96) | 0.379 |
| Lymphadenectomy | ||||||||
| No | Ref | Ref | Ref | Ref | ||||
| Yes | 0.50 (0.25–1.03) | 0.059 | 0.63 (0.28–1.38) | 0.244 | 0.51 (0.24–1.05) | 0.068 | 0.59 (0.28–1.25) | 0.170 |
PNI Prognostic Nutritional Index, SII Systemic immune-inflammation index, FIGO International Federation of Gynecology and Obstetrics, HGSC High-grade serous carcinoma