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. 2005 Jul;12(4):399–406. doi: 10.1101/lm.96605

Figure 4.

Figure 4.

Effect of D2 dopaminergic agents on response to spaced CS presentations. (A) Protocol for experiment. Mice were fear conditioned on Day 1 with three CS–US pairings in Context A. On Day 2, they were injected with vehicle or sulpiride (20 mg/kg) 45 min before or with quinpirole (1 mg/kg) 30 min before seven spaced CS presentations in Context B (20 min ITI). RC group spent equivalent times in Context B, but received no CS presentations. On Day 3, all mice were tested for freezing during three CS presentations in Context B, and the results are averaged in the graphs. (B) Freezing during the CS presentations. Mixed ANOVA significant only for time. (C) Freezing at Day 3 test, drug-free. (*) P < 0.05 compared with all other groups.