Table 1. Functional classification of target genes bound by ERα in MCF-7 cells in the presence of estradiol.
Gene | Description |
---|---|
Apoptosis | |
CASP7 | Caspase 7 |
IKBKG | Inhibitor of κ light polypeptide gene enhancer in B cells, kinase γ |
Carbohydrate metabolism | |
GLT25D2 | Glycosyltransferase 25 domain-containing 2 |
HK1 | Hexokinase 1 |
MDH1 | Malate dehydrogenase 1, NAD |
Cell adhesion | |
ANXA6 | Annexin A6 |
ANXA9 | Annexin A9 |
COL5A3 | Collagen, type V, α3 |
NINJ2 | Ninjurin 2 |
Cell-cell signaling | |
CTNNBIP1 | Catenin, β interacting protein 1 |
SEMA3B | Sema domain, Ig domain, short basic domain, secreted, (semaphorin) |
WISP2 | WNT1 inducible signaling pathway protein 2 |
WNT16 | Wingless-type MMTV integration site family, member 16 |
Cell growth/maintenance | |
CHPT1 | Choline phosphotransferase 1 |
EPS8 | Epidermal growth factor receptor pathway substrate 8 |
PRCC | Papillary renal cell carcinoma |
SEL1L | Sel-1 suppressor of lin-12-like (C. elegans) |
TBC1D3 | TBC1 domain family, member 3 |
Cell motility | |
CRKL | v-crk sarcoma virus CT10 oncogene homolog |
Cell cycle | |
ARKRD15 | Ankyrin repeat domain 15 |
BANP | BTG3 associated nuclear protein |
CDK5 | Cyclin-dependent kinase 5 |
RBL2 | Retinoblastoma-like 2 (p130) |
TUSC4 | Tumor suppressor candidate 4 |
Chromosome biogenesis | |
SMYD3 | SET and MYND domain-containing 3 |
Co-enzyme metabolism | |
COQ4 | Coenzyme Q4 homolog (yeast) |
MOCS2 | Molybdenum cofactor synthesis 2 |
Cytoskeleton | |
FGD3 | FYVE, RhoGEF, and PH domain-containing 3 |
KRT13 | Keratin 13 |
SPTBN4 | Spectrin, β, non-erythrocytic 4 |
TTID | Titin immunoglobulin domain protein (myotilin) |
TNS | Tensin |
Defense response | |
LY6E | Lymphocyte antigen 6 complex, locus E |
PGLYRP2 | Peptidoglycan recognition protein 2 |
TFF1 | Trefoil factor 1 |
TFF3 | Trefoil factor 3 |
DNA repair | |
RECQL4 | RecQ protein-like 4 |
Immune response | |
IL-20 | IL-20 |
Lipid metabolism | |
ALDH3B2 | Aldehyde dehydrogenase 3 family, member B2 |
PAFAH2 | Platelet-activating factor acetylhydrolase 2, 40 kDa |
PCYTIA | Phosphate cytidylyltransferase 1, choline, α isoform |
Protein metabolism and modification | |
AHSA1 | HA1, activator of heat shock 90-kDa protein ATPase homolog 1 |
B3Gn-T6 | β-1,3-N-acetylglucosaminyl transferase protein |
CST5 | Cystatin D |
FBXO33 | F-box protein 33 |
H11 | Protein kinase H11 |
HSPH1 | Heat shock 105-dKa/110-kDa protein 1 |
PKIB | Protein kinase (cAMP-dependent, catalytic) inhibitor β |
RPS6KL1 | Ribosomal protein S6 kinase-like 1 |
TIPARP | TCDD-inducible poly(ADP-ribose) polymerase |
TMPRSS3 | Transmembrane protease, serine 3 |
RNA processing | |
DDX23 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 |
PRPF31 | Pre-mRNA processing factor 31 homolog (yeast) |
QTRTD1 | Queuine tRNA-ribosyltransferase domain-containing 1 |
THOC3 | THO complex 3 Signal transduction |
P2RY6 | Pyrimidinergic receptor P2Y, G protein-coupled, 6 |
Steroid and drug metabolism | |
BAAT | Bile acid CoA:amino acid N-acyltransferase (glycine N-choloyltransferase) |
CYP1B1 | Cytochrome P450, family 1, subfamily B, polypeptide 1 |
CYP4F3 | Cytochrome P450, family 4, subfamily F, polypeptide 3 |
CYP4F11 | Cytochrome P450, family 4, subfamily F, polypeptide 11 |
STS | Steroid sulfatase, arylsulfatase C, isozyme S |
UGT2B15 | UDP glycosyltransferase 2 family, polypeptide B15 |
UGT2B17 | UDP glycosyltransferase 2 family, polypeptide B17 |
Transcriptional regulator | |
CARP | Cardiac ankyrin repeat protein |
ESR1 | Estrogen receptor 1 |
FLJ20097 | Hypothetical protein FLJ20097 |
FOXA1 | Forkhead box A1 |
NR0B2 | Nuclear receptor subfamily 0, group B, member 2 |
PHF15 | PHD finger protein 15 |
PPRC1 | PPAR, γ, coactivator-related 1 |
PROP1 | Prophet of Pit1, paired-like Hox transcription factor |
TRIM16 | Tripartite motif-containing 16 |
ZNF140 | Zinc finger protein 140 |
ZNF302 | Zinc finger protein 302 |
ZNF485 | Zinc finger protein 485 |
Transport | |
ABCA3 | ATP-binding cassette, sub-family A (ABC1), member 3 |
ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member |
ABCC11 | ATP-binding cassette, sub-family C (CFTR/MRP), member |
ABCG2 | ATP-binding cassette, sub-family G (WHITE), member 2 |
DSCR3 | Down syndrome critical region gene 3 |
NDUFA2 | NADH dehydrogenase 1 α subcomplex, 2 |
NDUFB9 | NADH dehydrogenase 1 β subcomplex, 9 |
P2RX7 | Purinergic receptor P2X, ligand-gated ion channel, 7 |
PDZK1 | PDZ domain-containing 1 |
PKD212 | Polycystic kidney disease 2-like 2 |
RAB7L1 | RAB7, member RAS oncogene family-like 1 |
SLC7A3 | Solute carrier family 7, member 3 |
SLC9A8 | Solute carrier family 9 (sodium/hydrogen exchanger), isoform |
SLC25A36 | Solute carrier family 25, member 36 |
SLC27A2 | Solute carrier family 27, member 2 |
SYT12 | Synaptotagmin XII |
UCRC | Ubiquinol-cytochrome c reductase complex (7.2 kDa) |
ZFYVE1 | Zinc finger, FYVE domain-containing |
Genes without an assigned function at this level of analysis: C9orf11, C14orf61, C14orf133, C20orf172, CBWD2, CHD1L, CYB561D2, DKFZp434B-1272, DKFZp547E1912, DKFZP5641122, DKFZP566J2046, DNC12, DOC1, Eny2, FAHD1, FAM3C, FEM1A, FLJ10871, FLJ11267, FLJ13710, FLJ20094, FLJ20772, FLJ31882, FLJ33761, FLJ33868, GREB1, HAGH, HSPC138, IGSF3, INVS, KIAA1536, KSP37, LOC90668, LOC114926, MDH1, MDS025, MGC8902, MGC10200, MGC11242, MGC26694, MGC35361, MGC47799, MR-1, MSMB, NALP6, NAV3, NUDCD1, PRUNE, RGN, S100A10, SCGB1D2, SMAP, SMILE, TFPT, TRIM51, TSNAX1P1, TSSC4, VEPH1, Y1F1B, ZMAT5. In the case that one locus could be assigned to two distinct genes, both genes were included in the analysis.