Table 1. Histomorphometrical analysis of bone formation in bioreactors.

Time point, weeks	Growth factor	Alginate, %	Vascular canals, %	Tissue, matrix %	Bone, tissue %
6	None	0.18 ± 0.25	7.44 ± 6.56	92.39 ± 6.80	99.82 ± 0.25
6	T/F	2.91 ± 2.85	17.81 ± 8.36	79.29 ± 10.79	97.10 ± 2.85
8	None	1.10 ± 1.56	18.55 ± 9.12	80.35 ± 10.68	98.90 ± 1.56
8	T/F	0.73 ± 0.84	14.06 ± 12.19	85.21 ± 11.91	99.28 ± 0.84
12	None	0.28 ± 0.40	7.83 ± 4.49	91.89 ± 4.09	99.71 ± 0.40
12	T/F	0.96 ± 1.23	6.00 ± 7.13	93.04 ± 8.36	99.04 ± 1.23

n = six bioreactors per time point, three of which contained TGF-β1 and FGF-2. Parameters were measured in cross sections through the middle of the bioreactor space (n = 3) for each bioreactor. Data are expressed as mean ± standard deviation. T/F indicates the inclusion of TGF-β1 and FGF-2 in the formulation.