Fig. 3.

Dnchc2 phenotypes. (A) The motor domain of Dnchc2 protein has six AAA (ATPase associated with cellular activities) motifs (A1–A6) (35). The Dnchc2^lln mutation in A6 is likely to disrupt the motor activity of the protein. The Dnchc2^GT mutation produced a truncated protein lacking all six of the AAA motifs. (B) Exencephaly (arrows) and reversal of heart looping (arrowhead) in Dnchc2 mutants at e10.5. (C) Occasional Dnchc2^GT mutants that survived to e13.5 showed polydactyly in both hindlimbs (asterisk) and forelimbs (FL).