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. 2025 Feb 18;15:5874. doi: 10.1038/s41598-025-89623-8

Table 2.

Characteristics of the included participants (stratified by cognitive function).

Characteristic Overall, N = 2665 Normal, N = 1511 CFD, N = 1154 P Value
Age, years 69.07 (68.69 ,69.45) 67.76 (67.41 ,68.12) 72.00 (71.21 ,72.78) < 0.001
Gender 0.003
Male,% 45.79 (43.69 ,47.90) 43.07 (40.01 ,46.18) 51.89 (48.23 ,55.53)
Female,% 54.21 (52.10 ,56.31) 56.93 (53.82 ,59.99) 48.11 (44.47 ,51.77)
Race < 0.001
Mexican American,% 3.42 (2.19 ,5.30) 2.46 (1.55 ,3.86) 5.58 (3.51 ,8.75)
Other Hispanic,% 3.79 (2.59 ,5.52) 2.13 (1.47 ,3.08) 7.52 (4.89 ,11.39)
Non-Hispanic White,% 79.77 (75.77 ,83.26) 85.36 (82.34 ,87.94) 67.22 (59.42 ,74.16)
Non-Hispanic Black,% 7.95 (5.94 ,10.57) 5.37 (3.89 ,7.37) 13.75 (9.97 ,18.67)
Other Race,% 5.07 (3.85 ,6.64) 4.68 (3.28 ,6.65) 5.93 (4.41 ,7.93)
Education < 0.001
< High school ,% 5.50 (4.30 ,7.01) 1.44 (0.76 ,2.68) 14.63 (11.72 ,18.10)
Completed High school,% 10.14 (8.04 ,12.72) 6.82 (5.25 ,8.81) 17.61 (13.34 ,22.88)
> High school ,% 84.34 (81.03 ,87.16) 91.74 (89.28 ,93.68) 67.70 (61.93 ,72.98)
Missing ,% 0.02 (0.00 ,0.08) 0.00 (0.00 ,0.00) 0.06 (0.01 ,0.24)
Martial_status < 0.001
Widowed/Divorced/Separated/Never married [n (%)] 34.27 (32.34 ,36.26) 31.11 (28.94 ,33.36) 41.38 (36.81 ,46.11)
Married/Living with partner,% 65.70 (63.71 ,67.64) 68.88 (66.62 ,71.05) 58.57 (53.85 ,63.14)
Missing ,% 0.02 (0.01 ,0.11) 0.02 (0.00 ,0.12) 0.05 (0.01 ,0.36)
PIR_group < 0.001
< 1.13,% 11.01 (9.30 ,13.00) 6.76 (5.43 ,8.38) 20.57 (17.58 ,23.93)
>=1.13,% 82.71 (80.21 ,84.95) 87.03 (84.19 ,89.41) 73.01 (69.74 ,76.04)
Missing ,% 6.28 (4.76 ,8.24) 6.22 (4.45 ,8.62) 6.42 (4.77 ,8.59)
BMI_group 0.11
Normal,% 26.33 (23.73 ,29.10) 25.36 (21.77 ,29.33) 28.49 (25.56 ,31.62)
Overweight ,% 35.98 (33.60 ,38.43) 35.88 (33.09 ,38.77) 36.20 (31.71 ,40.93)
Obesity ,% 37.23 (34.57 ,39.98) 38.52 (35.51 ,41.63) 34.33 (29.39 ,39.64)
Missing,% 0.46 (0.24 ,0.88) 0.23 (0.05 ,0.97) 0.98 (0.50 ,1.92)
Hypertension < 0.001
No,% 33.10 (30.84 ,35.45) 37.20 (34.08 ,40.43) 23.90 (20.32 ,27.90)
Yes,% 66.90 (64.55 ,69.16) 62.80 (59.57 ,65.92) 76.10 (72.10 ,79.68)
Diabetes 0.009
No,% 71.04 (68.69 ,73.29) 73.37 (70.16 ,76.36) 65.82 (61.91 ,69.53)
Yes,% 26.92 (24.36 ,29.64) 24.49 (21.12 ,28.20) 32.37 (28.63 ,36.35)
Missing,% 2.04 (1.34 ,3.09) 2.14 (1.31 ,3.48) 1.80 (0.99 ,3.25)
Smoking 0.6
No,% 49.48 (46.47 ,52.49) 49.96 (46.23 ,53.70) 48.39 (44.87 ,51.93)
Yes,% 50.49 (47.47 ,53.51) 50.01 (46.27 ,53.76) 51.57 (48.03 ,55.11)
Missing,% 0.03 (0.01 ,0.11) 0.02 (0.00 ,0.16) 0.03 (0.00 ,0.27)
Drinking < 0.001
Never,% 12.43 (10.44 ,14.73) 10.66 (8.69 ,13.01) 16.40 (13.72 ,19.48)
Moderate,% 41.70 (38.20 ,45.29) 45.56 (41.72 ,49.46) 33.03 (27.94 ,38.56)
Heavy,% 27.97 (25.25 ,30.87) 28.64 (25.31 ,32.22) 26.47 (22.77 ,30.54)
Missing,% 17.90 (15.70 ,20.32) 15.14 (12.85 ,17.75) 24.09 (20.81 ,27.71)
Physicial 0.003
Inacitve ,% 64.36 (60.29 ,68.22) 61.34 (56.25 ,66.19) 71.12 (67.04 ,74.89)
Less acitve,% 10.70 (9.14 ,12.47) 11.75 (10.04 ,13.70) 8.34 (6.18 ,11.16)
Active,% 24.77 (21.33 ,28.56) 26.84 (22.25 ,32.00) 20.10 (16.39 ,24.42)
Missing ,% 0.18 (0.06 ,0.53) 0.07 (0.02 ,0.29) 0.43 (0.11 ,1.68)
Stroke 0.001
No,% 93.92 (92.99 ,94.74) 95.52 (94.01 ,96.66) 90.35 (87.67 ,92.49)
Yes,% 6.01 (5.20 ,6.95) 4.45 (3.31 ,5.96) 9.51 (7.38 ,12.18)
Missing,% 0.06 (0.04 ,0.10) 0.03 (0.01 ,0.13) 0.14 (0.12 ,0.16)
Waist circumference, cm 102.45 (101.39 ,103.50) 102.55 (101.34 ,103.77) 102.22 (100.85 ,103.58) 0.7
Ghb,% 5.94 (5.89 ,5.99) 5.89 (5.82 ,5.97) 6.05 (5.97 ,6.14) 0.007
eGDR, mg/kg/min 6.38 (6.25 ,6.52) 6.54 (6.36 ,6.72) 6.03 (5.85 ,6.22) 0.001

Continuous variables are presented as survey-weighted mean (95% CI), categorical variables are presented as survey-weighted percentage (95% CI).

Wilcoxon rank-sum test for complex survey samples; chi-squared test with Rao & Scott’s second-order correction.