Fig. 1.

A strong linkage between low expression of RTN3 and IPF. The mRNA levels of RTN3 GSE150910 dataset (A). B HE staining, Masson staining, and IHC showed the RTN3 levels in lung tissue of mice treated by bleomycin on day 0, day14.and day 21. C Western blot analysis showed the RTN3 levels in the lung tissue of mice treated by bleomycin on day 0, day14.and day 21. D Western blot analysis exhibited the levels of COL1A1 and RTN3 in MRC5 cell lines treated with TGFβ on 0 h, 12 h and 24 h. E HE staining, Masson staining, and IHC showed the RTN3 levels in in lung tissues of healthy controls and IPF patients