Table 2.

Sensitivity and Specificity of the Cutoff Scores With the Highest Youden Index

	Cutoff	Sensitivity	Specificity	AUC
Controls vs presymptomatic
MoCA	<28	0.71	0.41	0.53
MMSE	<29	0.92	0.14	0.52
Controls vs prodromal
MoCA	<27	0.83	0.67	0.84
MMSE	<29	0.92	0.44	0.75
Presymptomatic vs prodromal
MoCA	<27	0.74	0.67	0.79
MMSE	<29	0.86	0.44	0.73
Presymptomatic vs prodromal and symptomatic
MoCA	<25	0.94	0.61	0.87
MMSE	<28	0.86	0.58	0.80

Abbreviations: AUC = area under the operating characteristic curve; MMSE = Mini-Mental State Examination; MoCA = Montreal Cognitive Assessment.