Table 2.

Spearman Correlation of Baseline Logarithmized cNfL and sNfL Levels With Clinical Characteristics of Patients With SMA

Clinical category	Sample size, n for CSF/serum	Correlation with cNfL ρ (CI)	p Value	Correlation with sNfL ρ (CI)	p Value
Age	88/78	0.23 (0.02 to 0.42)	0.030	0.30 (0.09 to 0.49)	0.007a
BMI	88/78	0.29 (0.09 to 0.47)	0.006	0.16 (−0.06 to 0.37)	0.161
Disease duration	82/78	0.14 (−0.08 to 0.34)	0.22	0.49 (0.30 to 0.64)	0.001a
HFMSE	71/74	0.12 (−0.11 to 0.35)	0.310	−0.15 (−0.36 to 0.09)	0.215
RULM	73/74	0.03 (−0.20 to 0.26)	0.774	−0.13 (−0.34 to 0.11)	0.285
ALSFRS-R	56/63	0.05 (−0.21 to 0.31)	0.692	−0.19 (−0.42 to 0.06)	0.130

Abbreviations: ALSFRS-R = Amyotrophic Lateral Sclerosis Functional Rating Scale–Revised; BMI = body mass index; ρ = rho; cNfL = neurofilament light chain in cerebrospinal fluid; HFMSE = Hammersmith Functional Motor Scale Expanded; RULM = Revised Upper Limb Module; sNfL = neurofilament light chain in serum.

^aAge and disease duration were strongly correlated.