Table 1.

Tryptase genotypes and associated BST levels and predicted upper limits dictated by additional TPSAB1 copy encoding α-tryptase.

Additional TPSAB1 copy number	0	1	2	3	4	6	10
Tryptase Genotypes* (TPSAB1, TPSB2)	β,β/β,β; α,β/β,β; α,β/α,β; α,β/β,β,β; β,β/β,β,β; β/α,β; β/β,β	αα,β/β,β; αα,β/α,β; αα,ββ/β,β; αα,ββ/α,ββ	αα,β/αα,β; ααα,β/β,β; ααα,β/α,β	ααα,β/αα,β	ααααα,β/β,β; ααααα,β/α,β	ααααα, β/ααα, β	ααααααααααα, β/α, β
BST (ng/mL), median (range)	4.1 (0–10.4)	13.6 (6.5–33.9)	22.5 (10.5–39.5)	27.3 (23.4–40)	37 (25.5–62.7)	87 (NA)	133 (110–156)
Upper 99.5%PI for BST (ng/mL)	11.4	36.2	62.2	88.8	115.9	171.2	285.1
Upper limit using BST /(1+copy) †	20	40	60	80	100	140	220

^*Tryptase genotypes identified to date for this number of TPSAB1 replications. In all cases TPSAB1 replications associated with elevated BST identified encode α-tryptase.

^†Upper limits were generate by inverting this formula such that the threshold was the current minor criterion of 20 ng/mL times one plus the replication number.