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[Preprint]. 2025 Jan 28:2025.01.28.635252. [Version 1] doi: 10.1101/2025.01.28.635252

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Extended Data Fig. 8: — a, Heatmap of normalized expression (logCPM) of canonical astrocyte marker genes in astrocytes grown with LRP1-KD and LDLR-KD neurons (n = 36). Annotations on the right of the plot show marker gene identity (yellow represents astrocytes, red oligodendrocytes). b, Barplot showing the number of DEGs in the astrocytes. Turquoise color shows upregulated genes (adj. p < 0.05 & log2(FC) > 0), beige color shows downregulated genes (adj. p < 0.05 & log2(FC) < 0) and purple color shows the number of significantly DE synaptic genes. c, Boxplots of normalized expression (logCPM) for cholesterol biosynthesis genes (n = 27) in astrocytes grown with LRP1-KD, LDLR-KD and NT-KD neurons. The boxplots’ limits show the upper- and lower quartile ranges, the center lines show the median values. The whiskers show the minimum and maximum values.