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[Preprint]. 2025 Jan 28:2025.01.28.635252. [Version 1] doi: 10.1101/2025.01.28.635252

Extended Data Fig. 3: Properties of latent factor.

Extended Data Fig. 3:

a,b, Heatmap of standardized expression (z-score logCPM) of the positive regulation of transcription by RNA polymerase I genes (c) and attachment of spindle microtubules to kinetochore (d) in astrocytes (n = 68). Annotations on the right of the plot show association of the gene with LF2, significance from differential expression analysis for day 2 to day 1, day 1 to 6 hours and CC day 2 to MC. c, Enrichment scores (ES) from GSEA of neurodevelopmental disorder (NDD) genes as gene set, against LF2 gene weights. The leading edge subset contributing most to the ES and top enrichment are marked with a dashed, red line. NDD genes highlighted in the ranked order of LF2 gene weights indicated on the x-axis.