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[Preprint]. 2025 Feb 6:2025.02.01.636039. [Version 1] doi: 10.1101/2025.02.01.636039

Figure 3: Consensus single cell Hierarchical Poisson Factorization (scHPF) reveals transcriptional co-expression patterns in infant and adult T cells.

Figure 3:

a) Schematic of consensus-scHPF analysis to identify co-expression patterns or “factors” across the dataset and multivariate linear regression to associate factors with metadata. b) Heatmap showing scHPF gene scores of the top 10 genes in each factor. Selected genes for each factor are indicated to the right and a ranked list of the top 100 genes in all factors is provided in Supplementary Table 3. c) Dot plots showing the rank and gene score for genes in selected scHPF factors with labels for the top genes. d) Heatmap of regression coefficients for multivariate linear regression between scHPF factor cell scores and covariates: age cohort (infant/adult), tissue localization (lymphoid/mucosal), T cell subset (naïveCM/effector), T cell lineage (CD4/CD8), or activation conditions (resting/activated).