Figure 1.
Effect of subcutaneous immunization on fibril Aβ levels in the brain. To measure Aβ fibrils, the left hemisphere of each mouse was cut into 14-μm longitudinal sections and stained with thioflavin S. Multiple sections from the identical regions were examined for each treatment group. The quantification was performed in a blinded fashion using Imaging Research software from the NIH. P < 0.01, Aβ versus control; P < 0.001, MOG, MOG B cell–deficient, and GA versus control.