Table 2.

Pathway significance. Pathways in the van 't Veer et al. [15] data set, ordered by significance and their number of transcription factors (TF) and downstream targets (DT). Also shown are Group Correlation Score (GCS) and Exclusive Group Correlation Score (EGCS) p-values. ER means both induced and repressed ER-pathway and (v) means that the pathway has been verified in a second experiment (see [14]).

Pathway	# of TF	# of DT	GCS p-value	EGCS p-value
IL-1	5	21	1e-04	4e-01
fMLP	9	27	4e-04	1e-01
TLR4	9	41	9e-04	1e-03
EDAR	6	41	3e-03	5e-02
ER-induced	1	50	3e-03	n/a
RANK	6	41	3e-03	5e-02
Oncostatin M	1	2	5e-03	n/a
PDGF	8	15	6e-03	2e-02
ER	1	77	7e-03	n/a
ER-induced(v)	1	5	7e-03	n/a
IL-4 – STAT6	1	6	8e-03	n/a
TGF-β network	7	23	1e-02	1e-02
EGF	12	53	1e-02	1e-02
ER (v)	1	7	2e-02	n/a
Insulin	7	45	2e-02	4e-02
VEGF	3	8	2e-02	2e-02
TNF-α	8	61	2e-02	5e-02
TPO	6	10	3e-02	2e-02
PRL	6	10	3e-02	2e-02
IFN	6	10	3e-02	2e-02
IL-10	2	7	5e-02	5e-02
IL-12 – STAT4	1	3	7e-02	n/a
c-Kit	4	87	8e-02	6e-02
ER-repressed	1	27	1e-01	n/a
B-cell antigen receptor	4	10	3e-01	3e-01
T-cell antigen receptor	4	10	3e-01	3e-01
Wnt pathway	2	8	4e-01	3e-01
ER-repressed (v)	1	2	6e-01	n/a
IL-2 – STAT5	2	4	8e-01	7e-01