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. 2005 Jun 22;5:11. doi: 10.1186/1471-213X-5-11

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Copyright © 2005 Jaskoll et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fgfr2c^+/Δ/Fgf10^+/-double heterozygous mutant SMG is severely hypoplastic. A. Newborn R2c^+/+/Fgf10^+/+WT SMG. B. Newborn R2c^+/Δ/Fgf10^+/+(Fgfr2c^+/Δ/Fgf10^+/+) single heterozygous mutant SMG. C. Newborn R2c^+/+/Fgf10^+/-(Fgfr2c^+/+/Fgf10^+/-) single heterozygous mutant SMG. D. Newborn R2c^+/Δ/Fgf10^+/-(Fgfr2c^+/Δ/Fgf10^+/-) double heterozygous mutant SMG. The Fgfr2c^+/Δ/Fgf10^+/+(B) and Fgfr2c^+/+/ Fgf10^+/-(C) single heterozygous SMGs have fewer ducts and terminal buds than seen in WT littermates (A). A much smaller, severely hypoplastic gland is seen in Fgfr2c^+/Δ/Fgf10^+/-double heterozygous mice (D) compared to Fgfr2c^+/Δ/Fgf10^+/+(B) and Fgfr2c^+/+/Fgf10^+/-(C) littermates. Bar, 50 μm.