Table 2.

Clinical trials assessing the efficacy of dietary interventions for psoriasis management

Database ID	Official title	Description	Study type
NCT06399432	Mediterranean diet vs no dietary intervention for improving signs and symptoms of psoriasis in patients treated with anti-IL-17 or anti-IL-23 inhibitors	This investigation aims to assess how the Mediterranean diet influences the effectiveness of anti-IL-17 or anti-IL-23 therapy in patients suffering from psoriasis, especially when compared to a lack of dietary intervention	Int
NCT03531528	A single-arm trial to evaluate the efficacy of an aggressive weight loss program with a ketogenic induction phase for the treatment of chronic plaque psoriasis	Additionally, the research explores whether implementing a rigorous weight loss program that includes a ketogenic phase can enhance treatment results for those dealing with chronic plaque psoriasis alongside obesity	Int
NCT01439425	Weight reduction alone may not be sufficient to maintain disease remission in obese patients with psoriasis: a randomized, investigator-blinded study	The study investigates the relationship between body weight and psoriasis severity using a questionnaire for 200 patients and compares a hypo-caloric diet to a free diet in obese psoriasis patients in remission over 24 weeks	Int
NCT05820698	A feasibility pilot study examining the effect of a Mediterranean style diet and time-restricted eating on individuals with mild-moderate psoriasis	The METRED-P study assesses the feasibility of a Mediterranean diet and/or time-restricted eating in mild to moderate psoriasis over 12 weeks	Int
NCT06574178	Use of total-body PET to quantify systemic and cutaneous inflammation in psoriasis patients before and after intervention with a nutritionally balanced diet	The study aims to assess whether a 6-week dietary intervention following nutrition guidelines can reduce measurable inflammation in psoriasis patients, using the advanced EXPLORER PET scanner technology	Int
NCT05118425	A real-world study of the dietary perceptions and practices in Chinese psoriasis patients	The study conducts a questionnaire-based survey to assess the dietary perceptions and behaviors of Chinese psoriasis patients across 25 medical institutions in China	Obs
NCT05448352	The APPLE study; a cross-sectional study exploring diet, life-style patterns and psoriasis severity	The goal of the study was to explore the relationship between specific dietary practices and lifestyle factors with the severity of psoriasis, utilizing an online survey alongside a four-day dietary log	Obs
NCT05892640	Effects of low salt dietary intake on Th17-mediated inflammation and vascular reactivity in patients with psoriasis	The study investigates the impact of a 2-week low-salt dietary approach on microvascular vasodilation and Th17-mediated inflammation in patients with psoriasis vulgaris	Int
NCT06164860	The effect of ketogenic diet versus Mediterranean diet on clinical and biochemical markers of inflammation and in patients with obesity and psoriatic arthritis	The study compares the effectiveness of the Mediterranean diet and the isocaloric ketogenic diet on inflammation markers in patients with obesity, psoriasis, and psoriatic arthritis over two 8-week periods	Int
NCT01714284	Efficacy study of dietary intervention and weight loss in improving psoriasis	Research is being conducted through a multicenter randomized controlled trial to determine the effectiveness of a structured weight reduction approach versus basic counseling in improving the management of psoriasis	Int
NCT03142503	Effectiveness of a dietary intervention program on disease activity, metabolism and oxidative stress in patients with psoriatic arthritis and psoriasis activity: a clinical, randomized, placebo-controlled trial	Focused on individuals with psoriasis and psoriatic arthritis, this study aims to evaluate the impact of a nutritional intervention program on disease activity, metabolic profiles, and oxidative stress	Int
NCT06257641	Impact of the Mediterranean diet on patients with psoriasis: a randomized clinical trial	In a separate effort, the MEDIPSO trial is designed to explore the benefits of a 16-week high-intensity Mediterranean diet on skin health in participants with mild to moderate psoriasis, comparing the results with those of a control group adhering to standard low-fat dietary guidelines	Int
NCT05590247	Role of intermittent fasting on disease severity and quality of life in psoriasis and psoriatic arthritis	The study evaluates intermittent fasting's effectiveness in improving psoriasis and psoriatic arthritis over 24 weeks, comparing an intermittent fasting group to a standard diet group	Int