Table 1. Summary of previous case reports of scleritis treated by topical cyclosporine.

Study	Patient	Diagnosis(s)	Initial treatment modality	Cyclosporine dose	Clinical course	Follow-up
Hoffmann and Wiederholt17	83/F	Cachexia Rheumatoid arthritis (onset 23 years prior to presentation) Necrotising scleritis of the right eye that started 6 months before presentation	Multimodal therapy with 1% atropine eye drops, Polyspectran eye drops, indomethacin eye drops, cysteine gel, chlorambucil and vitamin A ointments for 3 months	2% topical cyclosporine A in castor oil (two times per day)	All symptoms improved in 3 weeks, with almost complete symptom resolution within 6 weeks of treatment	No recurrence over 13 months of follow-up
Rosenfeld et al18	68/F	Inflamed right eye with large superonasal scleral nodule with reactive ptosis Developed a 5×3 mm zone of scleral necrosis 5 months after initial presentation	Topical prednisolone acetate, flurbiprofen sodium (0.03%), and oral indomethacin (25 mg; three times a day) The patient responded to oral sulindac (150 mg; two times per day) with topical prednisolone but was discontinued due to adverse reactions Oral prednisone (30 mg/day for 2 weeks, then 25 mg for 3 months) provided symptomatic relief but no improvement in scleral necrosis	2% topical cyclosporine in corn oil (four times a day)	Necrotising scleritis resolved after 4 weeks. Treatment tapered off completely over 12 weeks	No recurrence over 12 months of follow-up
Gumus et al19	35/F	Ocular myositis with scleritis on her left eye	Fluocortolone and a synthetic pure glucocorticoid (1 mg/kg body weight) for 8 months Oral cyclosporine (150 mg two times per day) for 6 months; discontinued due to adverse effects	0.05% topical cyclosporine A for 6 months plus dexamethasone for 1 month (both four times a day)	Symptom resolution within 1 month of treatment	No recurrence over 6 months of follow-up
Holland et al20	45/F60/F49/M78/F60/F	Scleritis	Not reported	Not reported	No effect of cyclosporine A alone in four patients, but adding it to the treatment regime comprising oral corticosteroids and azathioprine allowed tapering and discontinuation of all medications over 6 monthsCyclosporine A was discontinued in the 49/M patient due to severe discomfort.	Not reported