Table 2.
Plasma thiol/disulfide homeostasis in patients undergoing CPB surgerya.
| Variables | Preoperative CPB (n = 60) | Postoperative CPB (n = 60) | P-valueb |
|---|---|---|---|
| Albumin (gr/dL) | 4.19 (1.55) | 5.32 (0.62) | < 0.001d |
| IMA (ABSU) | 0.71 ± 0.10 | 0.80 ± 0.09 | < 0.001c |
| Native thiol (µmol/L) | 310.28 ± 64.78 | 197.38 ± 69.72 | < 0.001c |
| Total thiol (µmol/L) | 365.20 (66.28) | 233.18 (81.16) | < 0.001d |
| Disulfide bonds (µmol/L) | 17.99 (20.01) | 15.15 (8.51) | 0.001d |
| Reduced thiol (%) | 90.00 (13.63) | 86.52 (8.11) | 0.686d |
| Oxidized thiol (%) | 4.99 (6.81) | 6.90 (3.89) | 0.653d |
| Thiol oxidation-reduction (%) | 5.55 (9.43) | 7.82 (5.26) | 0.696d |
aData are expressed as mean ± standard deviation and median (interquartile range) where appropriate;b P<0.05 was considered significant; Obtained from paired samples t-test; dObtained from Wilcoxon test
ABSU=absorbance units; CPB=cardiopulmonary bypass; IMA=ischemia-modified albumin