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. 2024 Oct 18;46(3):539–553. doi: 10.1038/s41401-024-01400-x

Fig. 1. Different receptors and ion channels involved in the pruritus process.

Fig. 1

Under conditions of skin disease or pruritogen irritation, these receptors and ion channels are activated and play important roles in the itching process. GPCRs G protein-coupled receptors, Mrgpr MAS-related G protein-coupled receptor, BAM8-22 bovine adrenal medulla 8-22, IL-4/6/13/31/33 Interleukin-4/6/13/31/33, IL-31RA IL-31 receptor A, IL-4Rα IL-4 receptor α, IL-13Rα1 IL-13 receptor α1, IL-1RAcp IL-1 receptor accessory protein, ST2 growth stimulation expressed gene 2, PAR1/2 protease-activated receptor 1/2, TRPV1-4 transient receptor potential vanilloid 1–4, TRPC3/4 transient receptor potential canonical 3/4, TRPM8 transient receptor potential melastatin 8, ET-1 endothelin 1, TLRs Toll-like receptors, 5-HT 5-hydroxytryptamine, 5-HT2AR/5-HT7R 5-HT2A receptor/5-HT7 receptor, CXCR3 C-X-C motif chemokine receptor 3, BNP brain natriuretic peptide, TSLP thymic stromal lymphopoietin, SSRIs selective serotonin reuptake inhibitors, LPA lysophosphatidic acid, NPPB natriuretic peptide B, SST somatostatin, NPR1 natriuretic peptide receptor 1, H1R/H4R histamine H1/4 receptor, DRG dorsal root ganglion, OSMR onconstatin M receptor, Th2 T-helper 2 cell. Created with BioRender.com.