Table 1. Reported fatty acyl-CoA preferences of mouse Lass family members.
The Lass name is used in accordance with the mouse genome database (MGD) (http://www.informatics.jax.org/mgihome/submissions/submissions_menu.shtml). Preferred fatty acyl-CoAs have been reported for overexpressing cells [13,15] (*) and for lag1Δ lac1Δ yeast cells [14] (†). Percentage sequence identity and similarity are relative to Lass6. n.d., not determined.
| Current name | Old name | Accession no. | Identity/similarity (%) | Preference |
|---|---|---|---|---|
| Lass1 | UOG1*† | NM_138647 | 16.0/27.4 | C18:0*, C26:0† |
| Lass2‡ | trh3, clone 1† | BC006847 | 35.6/50.9 | C24:0† |
| Lass4 | trh1*, clone 4† | BC003946 | 37.2/51.2 | C18:0*, C20:0*†, C24:0† |
| Lass5 | trh4* | BC046797 | 61.7/68.2 | C16:0* |
| Lass6 | trh1-like | BC057629 | 100/100 | n.d. |
‡ We found that the human Lass2 reported previously [34] was truncated at its N-terminus. Since the truncated N-terminus was essential for its activity (results not shown), the mouse Lass2 used here contained an additional 150 amino acids compared with the previously reported human protein.