Table 2. Effects of FGF23 on serum levels of calcium, Pi, 1,25(OH)2D3 and PTH in VDR(+/+) and VDR(−/−) mice at 4 days after injection.
One-way ANOVA (post hoc Scheffé F-test) and two-factor factorial ANOVA were performed. Values are means±S.E.M. (n=6–10). Significance of differences: *P<0.05 compared with VDR(+/+) (mock); †P<0.005 compared with VDR(+/+) (FGF23WT); ‡P<0.005 compared with VDR(−/−) (mock); §P<0.05 compared with VDR(−/−) (FGF23WT).
| VDR(+/+) | VDR(−/−) | |||||
|---|---|---|---|---|---|---|
| Mock | FGF23WT | FGF23M | Mock | FGF23WT | FGF23M | |
| Calcium (mg/dl) | 9.02±0.14 | 9.03±0.23 | 9.24±0.24 | 6.61±0.52* | 6.90±0.39 | 7.46±0.16 |
| Pi (mg/dl) | 7.43±0.40 | 7.43±0.31 | 5.87±0.16*† | 5.73±0.27* | 5.12±0.30 | 3.59±0.36‡§ |
| 1,25(OH)2D3 (pg/ml) | 82±16 | 130±47 | 6±0.16*† | 630±6* | 617±16 | 610±8 |
| PTH (pg/ml) | 19.3±3.0 | 18.5±2.3 | 16.0±1.0 | 343±25.9* | 281±47.6 | 277±25.3 |