Table 3. Effects of injection of FGF23M on intestinal and renal Na+-dependent Pi transport activity in VDR(+/+) and VDR(−/−) mice.
Na+-dependent Pi co-transport activity was assessed by the measurement of Pi uptake into intestinal or renal BBMVs. One-way ANOVA (post hoc Scheffé F-test) and two-factor factorial ANOVA were performed. Values are means±S.E.M. (n=5–6). Significance of differences: *P<0.05 compared with mock; †P<0.05 compared with FGF23WT.
| Pi uptake (nmol/30s per mg of protein) | ||||||
|---|---|---|---|---|---|---|
| VDR(+/+) | VDR(−/−) | |||||
| Mock | FGF23WT | FGF23M | Mock | FGF23WT | FGF23M | |
| Intestine | 0.533±0.03 | 0.467±0.070 | 0.304±0.050*† | 0.338±0.040 | 0.364±0.020 | 0.315±0.060 |
| Kidney | 1.024±0.133 | 0.984±0.100 | 0.743±0.040*† | 1.104±0.171 | 0.960±0.161 | 0.733±0.060*† |