Figure 4.

Comparison of membrane remodeling activity and induced scission necks by viral protein M2 from influenzas A and eukaryotic fission protein Dnm1. (A) Estimation of induced scission necks by M2 protein of influenza A virus and Dnm1 in different lipid compositions, using our mechanical framework and the cubic lattice constants measured in our previous SAXS experiments.^22,23 The M2 protein of influenza A virus can form narrow constricted necks <10 nm within the range of possible hemifission regime in different lipid compositions. (B) Estimation of induced scission necks by M2TM-cyto peptide in different lipid compositions, and the full-length M2 protein under neutral (pH 7) and acidic (pH 5) conditions. The M2 induces smaller scission neck sizes in acidic conditions. In both panels, we considered 20% variations in neck length ($s_0=10\text{nm}$) and effective contact surface area $a_{\mathrm{p}}$ ($\gamma =0$).