Table 2.

Drugs targeting KLF4 and their mechanisms.

	Compounds	Mechanism	Reference
KLF4	WX2-43	Promotes PRMT5-KLF4 interaction	(162)
	Kenpaullone	Suppress CDK1/cyclin B and GSK-3β	(163)
	Sulforaphane	Enhances KLF4-p21 signaling	(163)
	Regorafenib	Regulates Creb1/KLF4 Promotes M1 macrophage polarization	(165)
	APTO-253	Makes cells susceptible to NK cells	(167)
	Pioglitazone	Activates the AKT pathway and reduces KLF4 ubiquitination	(168, 169)
	H89 and 14–22 Amide (PKI)	Enhance KLF4 transcription	(176, 177)
	Decitabine	Suppress EMT pathway	(170)