TABLE 7.

Type of bonding and amino acid residues of target proteins that interact with drug compounds.

S.No	Receptors	Compounds	Binding affinity	Bonding type	Bond category	Amino acid residues
1	PD-L1	THC	−8.2	Hydrogen	Conventional	ASN131
				Hydrophobic	Alkyl	ALA137, VAL29,LYS129, ALA132, LEU106
					Pi-Alkyl	LYS129
2	PD1	THC	−6	Hydrogen	Conventional	ASP117
				Hydrophobic	Pi-Sigma	ARG69
					Pi-Alkyl	PHE95
					Alkyl	PRO72
3	MMP9	THC	−8.2	Hydrogen	Conventional	PRO430
					Carbon	GLU416
				Hydrophobic	Pi-Alkyl	HIS401
4	IL-6	THC	−6.8	Hydrophobic	Alkyl	ARG182, LEU178, LEU33, ILE36, LYS171
					Pi-Alkyl	LEU33, LEU178
5	TNF-a	CBD	−7.7	Hydrogen	Conventional	GLN102
6	AGEs	THC	−6.9	Hydrogen	Conventional	ARG69
					Carbon	GLY75
				Hydrophobic	Amide-Pi Stacked	VAL95
					Alkyl	ARG94, PRO101, PRO104, ARG96
					Pi-Alkyl	ARG96
		CBD	−6.4	Hydrophobic	Alkyl	ILE100, PRO101, ARG94, ARG96
					Pi-Alkyl	ARG96
7	AKT1	THC	−9.6	Hydrophobic	Pi-Pi Stacked	TYR272
					Alkyl	LYS268, VAL270, LEU264
					Pi-Alkyl	TRP80