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. 2025 Feb 19;14(2):217. doi: 10.3390/biology14020217

Figure 3.

Figure 3

Widespread innervation and maturation of human iGABAs 9-month post-transplantation in RNU-NUDE rat brain. (A) Stereological quantification of cell survival (total human-nuclei+ cell). (B) Distribution of transplanted human-nuclei+ cells in the striatum and corpus callosum. Scale = 1000 μm. (C) High magnification of human-nuclei+ cells within the striatal graft core cell deposit. Scale = 25 μm. (D) Human NCAM+ iGABA grafts course the entire neuraxis at 9 months post-injection in the aged immunodeficient rat. (E–G) Engrafted mature human (Human Nuclei, red) express medium spiny neuron marker Darpp32 (green). Scale = 20 μm. (H–J) Engrafted mature human (human nuclei, red) express striatal neuron marker Calbindin (green). Scale = 20 μm.