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. 2025 Feb 13;14(4):276. doi: 10.3390/cells14040276
AD Alzheimer’s disease
PD Parkinson’s disease
HD Huntington’s disease
ALS amyotrophic lateral sclerosis
amyloid-β
MPTP 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
ETC electron transport chain
ROS reactive oxygen species
mtDNA mitochondrial DNA
ER endoplasmic reticulum
MAMs mitochondria-associated membranes
OMM outer mitochondrial membrane
IMM inner mitochondrial membrane
IMS intermembrane Space
OXPHOS oxidative phosphorylation
NADH nicotinamide adenine dinucleotide
FADH2 flavian adenine dinucleotide
ATP adenosine triphosphate
ADP adenosine diphosphate
Mfn1/2 MItofusin 1/2
OPA1 optic atrophy 1
Drp1 dynamin-related protein 1
Fis1 fission1
Mff mitochondrial fission factor
MiD49 mitochondrial dynamics protein 49
MCU mitochondrial calcium uniporter
mPTP mitochondrial permeability transition pore
NCLX Na+/Ca2+ exchanger
UPS Uniquitin-proteasome System
MDVs Mitochondrial-derived Vesicles
PINK1 PTEN-induced Kinase 1
SQSTM1 Sequestosome 1
NBR1 neighbor of BRCA1 gene
OPTN optineurin
BNIP3 Bcl-2/adenovirus E1B 19 kDa-interacting protein 3
FUNDC1 FUN14 domain-containing 1
SOD Superoxide Dismutase
ABAD amyloid-beta-binding alcohol dehydrogenase
TDP-43 TAR DNA-binding protein-43
DAMPs damage-associated molecular patterns
FUS fused in sarcoma
PGC-1α peroxisome proliferator-activated receptor gamma coactivator 1-alpha
fAD familial AD
APP amyloid precursor protein
PSEN presenilin
sAD sporadic AD
APOE apolipoprotein E
LRRK2 leucine-rich repeat kinase 2
SNCA α-synuclein
fALS/sALS familial/sporadic ALS
NAD nicotinamide adenine dinucleotide
SIRT1 sirtuin 1
NAM nicotinamide
USP30 ubiquitin-specific Peptidase 30
DCA dichloroacetate
BBB blood–brain barrier
CSF cerebrospinal fluid
8-OHdG 8-hydroxy-2′-deoxyguanosine
FGF21 fibroblast growth factor 21
GDF15 growth differentiation factor 15
PET Positron Emission Tomography
CRISPR/Cas9 clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9
iPSC induced pluripotent stem cell
UPRmt mitochondrial unfolded protein response