Table 2.
Weighted adjusted hazard ratios of phenotypic age acceleration with risk of all-cause mortality and cause-specific mortality
| Characteristics | Age acceleration residual | P-value | Phenotypic age acceleration | P-value | |
|---|---|---|---|---|---|
| No | Yes | ||||
| All-cause mortality | |||||
| Model 1 | 1.04 (1.03–1.05) | < 0.001 | 1 (reference) | 2.31 (1.93–2.77) | < 0.001 |
| Model 2 | 1.04 (1.03–1.05) | < 0.001 | 1 (reference) | 2.15 (1.76–2.62) | < 0.001 |
| Model 3 | 1.04 (1.03–1.05) | < 0.001 | 1 (reference) | 2.07 (1.69–2.54) | < 0.001 |
| Cancer mortality | |||||
| Model 1 | 1.04 (1.03–1.05) | < 0.001 | 1 (reference) | 2.34 (1.71–3.19) | < 0.001 |
| Model 2 | 1.04 (1.03–1.05) | < 0.001 | 1 (reference) | 2.10 (1.51–2.90) | < 0.001 |
| Model 3 | 1.04 (1.03–1.05) | < 0.001 | 1 (reference) | 2.15 (1.52–3.04) | < 0.001 |
| Non-Cancer mortality | |||||
| Model 1 | 1.04 (1.03–1.05) | < 0.001 | 1 (reference) | 2.32 (1.91–2.81) | < 0.001 |
| Model 2 | 1.04 (1.03–1.05) | < 0.001 | 1 (reference) | 2.19 (1.76–2.73) | < 0.001 |
| Model 3 | 1.04 (1.03–1.05) | < 0.001 | 1 (reference) | 2.06 (1.66–2.57) | < 0.001 |
Model 1 was adjusted for age and gender. Model 2 was additionally adjusted for race, marital status, PIR group, educational level, BMI, HEI-2015, physical active, smoking status, and alcohol intake. Model 3 was additionally adjusted for CVD, hypertension, hyperlipidemia, and diabetes
Abbreviations: BMI, body mass index; HEI-2015, Healthy Eating Index-2015; PIR, poverty income ratio; CVD, cardiovascular disease