Table 3.
Weighted adjusted hazard ratios of phenotypic age acceleration with risk of all-cause mortality and cause-specific mortality after excluding deaths within 2 years
| Characteristics | Age acceleration residual | P-value | Phenotypic age acceleration | P-value | |
|---|---|---|---|---|---|
| No | Yes | ||||
| All-cause mortality | |||||
| Model 1 | 1.04 (1.03–1.05) | < 0.001 | 1 (reference) | 2.19 (1.83–2.62) | < 0.001 |
| Model 2 | 1.04 (1.03–1.05) | < 0.001 | 1 (reference) | 2.02 (1.67–2.44) | < 0.001 |
| Model 3 | 1.04 (1.03–1.05) | < 0.001 | 1 (reference) | 1.95 (1.60–2.36) | < 0.001 |
| Cancer mortality | |||||
| Model 1 | 1.04 (1.02–1.05) | < 0.001 | 1 (reference) | 2.08 (1.51–2.87) | < 0.001 |
| Model 2 | 1.04 (1.02–1.05) | < 0.001 | 1 (reference) | 1.89 (1.37–2.62) | < 0.001 |
| Model 3 | 1.04 (1.02–1.05) | < 0.001 | 1 (reference) | 1.94 (1.37–2.74) | < 0.001 |
| Non-Cancer mortality | |||||
| Model 1 | 1.04 (1.03–1.05) | < 0.001 | 1 (reference) | 2.24 (1.84–2.74) | < 0.001 |
| Model 2 | 1.04 (1.03–1.05) | < 0.001 | 1 (reference) | 2.08 (1.66–2.61) | < 0.001 |
| Model 3 | 1.04 (1.03–1.05) | < 0.001 | 1 (reference) | 1.97 (1.57–2.46) | < 0.001 |
Model 1 was adjusted for age and gender. Model 2 was additionally adjusted for race, marital status, PIR group, educational level, BMI, HEI-2015, physical active, smoking status, and alcohol intake. Model 3 was additionally adjusted for CVD, hypertension, hyperlipidemia, and diabetes
Abbreviations: BMI, body mass index; HEI-2015, Healthy Eating Index-2015; PIR, poverty income ratio; CVD, cardiovascular disease