Table 3.

Studies showing p16 alterations in tissue specimen of primary pancreatic ductal adenocarcinomas.

Study	Number of cases	p16 gene alterations
		Homozygous deletion	Mutation	Methylation
Huang et al (1996)	30	10%	17%	NE
Zhonghua et al (2000)	35	35%	20%	NE
Moore et al (2002)	34	NE	23%	15%
Gerdes et al (2002)	40	ND	22.5%	27.5%
Ohtsubo et al (2003)	60	ND	15%	3.3%
Present study	25	12%	16%	52%

NE: Not Examined; ND: Not Detected