Table 1.
Indices of cytotoxicity (IC50) to several cancer drugs founded in multicellular spheroids and monolayer.
| Drug | Monolayers IC50 (μM) | Multicell. spheroids IC50 (μM) | ||||
| INER-51 | PCS-1 | RR | INER-51 | PCS-1 | RR | |
| Doxorubicin | 6.2 | 9.2 | 1.4 | 15 | 9.8 | 0.6 |
| Etoposide | 2.2 | 4.1 | 1.8 | >50 | >50 | ---- |
| Methotrexate | 0.8 | 2.8 | 3.5 | >50 | >50 | ---- |
Drug exposition was continuous for 72 hours and drug cytotoxicity was performed by MTT assay. IC50: Fifty percent of the decrease in the survival rate. RR: The value of relative resistance of INER-51 cells vs PSC-1 cells as monolayers or multicellular spheroids.