Skip to main content
. 2025 Feb 5;15(2):242. doi: 10.3390/life15020242

Figure 6.

Figure 6

Representative photomicrographs of the skin tissue in the experimental groups. Epithelial degeneration and dermal edema were observed in the control group (A). Regular organization of the epidermal and dermal layers compared to the control groups with regional hair follicular disruption was observed in the (B) D-TN6 MICX20, (C) D-TN6 MICX40, and (D) ampicillin MICX40 groups. Masson’s trichrome staining. Scale bars are 100 µm for A, B, C, and D and 50 µm for inner images in B and C. (E) Wound healing (%) in rats in the D-TN6 (MICX20 or MICX40), ampicillin (MICX40), or SF-treated control groups on days 4, 6, 8, and 10 in the full-thickness excision wound model. Results are presented as means ± SEM; **: p < 0.01; ***: p < 0.001 vs. day 2. # p < 0.05; ##: p < 0.01 vs. the control group. (F) Skin tissue histopathological score graph. Results are presented as means ± SEM; ***: p < 0.001 versus control. (G) Infection in a rat infection model. Viable counts of bacteria in the D-TN6 (MICX40), ampicillin (MICX40), or SF-treated wound groups at 3 h post-operation. MICX20 refers to the 20-fold MIC concentration; MICX40 refers to the 40-fold MIC concentration against S. aureus. Results are presented as means ± SEM; *: p < 0.05; **: p < 0.01 versus the control.