Table 2.
Analysis of IC50 values of NDM inhibitors.
| Compounds | Substrates | Enzymes | Activity IC50 (μM) |
Pathogens | Ref. |
|---|---|---|---|---|---|
| Ag2O2@BP-MT@MM | Meropenem | NDM-1 | 0.24 | KP | [50] |
| Risedronate, Methotrexate, D-captopril | Nitrocefin, ampicillin, cefotaxime, imipenem, meropenem | NDM-1 | 24.6, 29.7, 11.8 | EC | [51] |
| Xeruborbactam | Meropenem, cefepime | NDM-1, NDM-9 | 0.24–1.2 | EC, KP | [52] |
| Hydroxamates | Meropenem, cefazolin | IMP, NDM-1, VIM-2, Li, ImiS (B2) | 0.1–0.23 | Not specified | [53] |
EC: Escherichia coli; KP: Klebsiella pneumoniae; IC50: half maximal inhibitory concentration.