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. 2025 Feb 17;17(2):276. doi: 10.3390/v17020276

Figure 18.

Figure 18

Host genetic background effects on intrastrain variation in the ratio of liver and spleen VCN. The CV (SD/mean) of the ratios of liver and spleen VCN in each CC mouse strain was employed to identify genomic loci associated with intrastrain variation in the above phenotype. (A) The LOD scores across all chromosomes. The horizontal red, blue, and green lines indicate the 5%, 10%, and 20% genome-wide significance threshold, respectively (based on a permutation test). (B) The LOD score for chromosome 4. (C) The estimated QTL effects of eight haplotypes among markers near the peak of QTL. (D) Dot plot showing the CV of the ratio of liver and spleen VCN in CC mouse stains carrying one of the eight founder alleles at the above QTL on chromosome 4. Note that four mouse strains carrying the 129s1/SvImJ haplotype exhibit the highest CVs.