Table 2.
Spontaneous epidermal tumor development in FVB keratin-5–matriptase mice
| Mouse | Gender | Age at analysis (months) | Diagnosis of skin lesions |
|---|---|---|---|
| FVB-K5—Mat-A-1 | Male | 12 | Epidermal papilloma with dermal inflammation. |
| FVB-K5—Mat-A-2 | Male | 12 | Moderately differentiated ulcerative squamous cell carcinoma with focal anaplasia lacking obvious squamous differentiation. Dermal and subdermal invasion with infiltration and destruction of adipose and muscle tissue. |
| FVB-K5—Mat-A-3 | Male | 13 | Epidermal papilloma, dysplasia, and dermal inflammation. |
| FVB-K5—Mat-A-4 | Female | 13 | Moderately differentiated ulcerative squamous cell carcinoma. Dermal and subdermal invasion with destructioin of adipose and muscle tissue. Diffuse infiltration of mammary gland. |
| FVB-K5—Mat-A-5 | Male | 14 | Epidermal papilloma, dysplasia, and dermal inflammation. |
| FVB-K5—Mat-A-6 | Female | 15 | Moderately differentiated ulcerative squamous cell carcinoma. Dermal and subdermal invasion with destruction of adipose and muscle tissue. |
| FVB-K5—Mat-A-7 | Female | 19 | Squamous cell carcinoma with dermal invasion. |
| FVB-K5—Mat-A-8 | Male | 21 | Ulcerative squamous cell carcinoma. Biphasic with zones of well-differentiated squamous cell carcinoma mixed with zones of spindle-shaped carcinoma. Infiltration of muscle and adipose tissue. |
| FVB-K5—Mat-A-9 | Female | 23 | Ulcerative squamous cell carcinoma. Biphasic with zones of moderately differentiated squamous cell carcinoma mixed with zones of spindle-shaped carcinoma. Infiltration and destruction of muscle and adipose tissue. |
| FVB-K5—Mat-A-10 | Female | 23 | Moderately differentiated ulcerative squamous cell carcinoma. Dermal invasion reaching panniculus muscle. |
No epidermal tumors were found in age-matched wild-type FVB control mice.