Table 2.
Running enrichment score for 10 selected modes of actions from pre-trained baseline EfficientNetB0 model
| Mechanism of Action (MOA) | es from CellProfiler (CP) features | average CP per target | es from EfficientNetB0 features with unmasked bounding box | average NN per target | es from EfficientNetB0 features with masked bounding box | Average NN per target (masked) | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| KB | KW | MHB | O3B | O8W | KB | KW | MHB | O3B | O8W | KB | KW | MHB | O3B | O8W | ||||
| BET | 80.0 | 86.7 | 75.6 | 55.6 | 75.6 | 74.7 | 68.9 | 77.8 | 71.1 | 60.0 | 64.4 | 68.4 | 88.9 | 48.9 | 66.7 | 51.1 | 55.6 | 62.2 |
| CDK | 70.0 | 73.3 | 26.7 | 36.7 | 41.7 | 49.7 | 51.7 | 35.0 | 35.0 | 73.3 | 6.7 | 40.3 | 61.7 | 68.3 | 23.3 | 23.3 | 43.3 | 44.0 |
| EGFR | 71.3 | 48.8 | 81.3 | 76.3 | 13.8 | 58.3 | 37.5 | 41.3 | 85.0 | 85.0 | 16.3 | 53.0 | 68.8 | 60.0 | 78.8 | 82.5 | 27.5 | 63.5 |
| HDAC | 69.5 | 77.1 | 72.1 | 50.5 | 74.3 | 68.7 | 63.8 | 76.2 | 51.0 | 75.2 | 68.6 | 67.0 | 54.3 | 61.0 | 55.8 | 53.3 | 63.8 | 57.6 |
| MEK1/2 | 73.3 | 33.3 | 93.3 | 86.7 | 76.7 | 72.7 | 70.0 | 23.3 | 96.7 | 90.0 | 80.0 | 72.0 | 66.7 | 53.3 | 76.7 | 83.3 | 76.7 | 71.3 |
| Mitotic | 73.3 | 91.1 | 73.3 | 71.1 | 75.6 | 76.9 | 77.8 | 66.7 | 66.7 | 82.2 | 68.9 | 72.4 | 80.0 | 73.3 | 57.8 | 62.2 | 66.7 | 68.0 |
| PARP | 60.0 | 76.0 | 52.0 | 88.0 | 68.0 | 68.8 | 68.0 | 72.0 | 68.0 | 80.0 | 72.0 | 72.0 | 64.0 | 84.0 | 88.0 | 88.0 | 76.0 | 80.0 |
| PI3K | 66.2 | 25.4 | 38.8 | 62.3 | 34.6 | 45.4 | 31.5 | 53.8 | 27.1 | 73.1 | 56.9 | 48.5 | 62.3 | 42.3 | 33.3 | 73.8 | 34.6 | 49.3 |
| Topoisomerase | 70.0 | 90.0 | 75.0 | 58.3 | 76.7 | 74.0 | 55.0 | 80.0 | 58.3 | 73.3 | 78.3 | 69.0 | 68.3 | 70.0 | 61.7 | 61.7 | 71.7 | 66.7 |
| VEGFR | 28.4 | 32.6 | 52.6 | 35.8 | 35.8 | 37.1 | 42.1 | 36.8 | 33.7 | 48.4 | 13.7 | 34.9 | 64.2 | 32.6 | 37.9 | 55.8 | 47.4 | 47.6 |
| Average | 66.2 | 63.4 | 64.1 | 62.1 | 57.3 | 62.6 | 56.6 | 56.3 | 59.3 | 74.1 | 52.6 | 59.8 | 67.9 | 59.4 | 58.0 | 63.5 | 56.3 | 61.0 |
| es > 80 | 7.0 | es > 80 | 5.0 | es > 80 | 6.0 | |||||||||||||
| es > 75 | 16.0 | es > 75 | 13.0 | es > 75 | 11.0 | |||||||||||||
| es > 70 | 25.0 | es > 70 | 19.0 | es > 70 | 14.0 | |||||||||||||
| es > 65 | 30.0 | es > 65 | 27.0 | es > 65 | 21.0 | |||||||||||||
| es > 60 | 31.0 | es > 60 | 29.0 | es > 60 | 30.0 | |||||||||||||